Publications
Addiction
Shiflett, M.W., Riccie, M., DiMatteo, R. The effects of amphetamine sensitization on conditioned inhibition during a Pavlovian-instrumental transfer task in rats. Psychopharmacology 230(1):137-47 doi.org/10.1007/s00213-013-3144-3 (2013)
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Shiflett, M.W. The effects of amphetamine exposure on outcome-selective Pavlovian-instrumental transfer in rats. Psychopharmacology 223(3) 361-70 (2012) doi.org/10.1007/s00213-012-2724-y
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ADHD
Natsheh, J.Y., Espinoza, D., Bhimani, S. and Shiflett, M.W. The effects of the dopamine D2/3 agonist quinpirole on incentive value and palatability-based choice in a rodent model of attention-deficit/hyperactivity disorder. Psychopharmacology 238, 3143-53 (2021) doi.org/10.1007/s00213-021-05931-7
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Natsheh, J.Y., and Shiflett, M.W. Dopaminergic Modulation of Goal-Directed Behavior in a Rodent Model of Attention-Deficit/Hyperactivity Disorder. Frontiers in Integrative Neuroscience 12, 45. (2018) doi.org/10.3389/fnint.2018.00045
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Natsheh, J. Y. and Shiflett, M. W. The Effects of Methylphenidate on Goal-Directed Behavior in a Rat Model of ADHD. Frontiers in Behavioral Neuroscience 9 (2015) doi:10.3389/fnbeh.2015.00326.
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Autism Spectrum Disorder
Subramanian D, Eisenberg C, Huang A, Baek J, Naveed H, Komatireddy S, Shiflett MW, Tran TS, Santhakumar V. Dysregulation of neuropilin-2 expression in inhibitory neurons impairs hippocampal circuit development and enhances risk for autism-related behaviors and seizures. Mol Psychiatry. 2025 Jul;30(7):2799-2809. doi: 10.1038/s41380-024-02839-4.
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Eisenberg, C., Subramanian, D., Afrasiabi, M., Ziobro, P., DeLucia, J., Hirschberg, P.R., Shiflett, M.W., Santhakumar, V., Tran, T.S.. Reduced hippocampal inhibition and enhanced autism-epilepsy comorbidity in mice lacking neuropilin 2. Translational Psychiatry 11, 537 (2021). https://doi.org/10.1038/s41398-021-01655-6
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Assous, M., Martinez, E., Eisenberg, C., Shah, F., Kosc, A., Varghese, K., Espinoza, D., Bhimani, S., Tepper, J.M., Shiflett, M.W., Tran, T.S.. Neuropilin 2 signaling mediates corticostriatal transmission, spine maintenance, and goal-directed learning in mice. Journal of Neuroscience Nov 6;39(45):8845-8859 (2019) doi:10.1523/JNEUROSCI.1006-19.2019
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Shiflett, M. W., E. Martinez, H. Khdour and T. S. Tran Functions of Neuropilins in Wiring the Nervous System and Their Role in Neurological Disorders. The Neuropilins: Role and Function in Health and Disease. Neufeld and Kessler. Berlin, Springer-Verlag (2017).
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Shiflett, M.W., Gavin, M., Tran, T.S. Altered hippocampal-dependent memory and motor function in Neuropilin 2-deficient mice. Translational Psychiatry e521 (2105) doi:10.1038/tp.2015.17
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Striatum
Kim Y, Gut NK, Shiflett MW, Mena-Segovia J. Inhibition of midbrain cholinergic neurons impairs decision-making strategies during reversal learning. Front Mol Neurosci. 2024 Nov 21;17:1481956. doi: 10.3389/fnmol.2024.1481956.
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Kaminer, J., Espinoza, D., Bhimani, S., Tepper, J.M., Koos, T., Shiflett, M.W. Loss of striatal tyrosine-hydroxylase interneurons impairs instrumental goal-directed behavior. European Journal of Neuroscience 2019 Aug;50(4):2653-2662. (2019) doi 10.1111/ejn.14412
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Shiflett M.W., and Balleine B.W. Molecular substrates of action control in striatal circuits. Progress in Neurobiology 95(1): 1-13 (2011) doi.org/10.1016/j.pneurobio.2011.05.007
Shiflett, M.W., and Balleine B.W. Contributions of ERK signaling in the striatum to instrumental learning and performance. Behavioral Brain Research 218(1): 240-7 (2011) https://doi.org/10.1016/j.bbr.2010.12.010
Shiflett, M.W., and Balleine, B.W. At the limbic-motor interface: disconnection of basolateral amygdala from nucleus accumbens core and shell reveals dissociable components of incentive motivation. European Journal of Neuroscience 32(10): 1735-43 (2010) https://doi.org/10.1111/j.1460-9568.2010.07439.x
Shiflett, M.W., Brown, R.A., and Balleine, B.W. Acquisition and performance of goal-directed instrumental actions depends on ERK signaling in distinct regions of dorsal striatum in rats. Journal of Neuroscience 30(8): 2951-9 (2010) https://doi.org/10.1523/jneurosci.1778-09.2010
Shiflett, M.W., Mauna, J.C., Chipman, A.M., Peet, E. and Thiels, E. Appetitive Pavlovian conditioned stimuli increase CREB phosphorylation in the nucleus accumbens. Neurobiology of Learning and Memory 92(3): 451-4 (2009) https://doi.org/10.1016/j.nlm.2009.02.010
Shiflett, M.W., Martini, R.P., Mauna, J., Foster, R.L., Peet, E. and Thiels, E. Cue-elicited reward seeking requires Extracellular Signal-Regulated Kinase activation in the Nucleus Accumbens. Journal of Neuroscience 28(6): 1434-43 (2008) https://doi.org/10.1523/jneurosci.2383-07.2008
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Cerebellum and TBI
Corrubia L, Huang A, Nguyen S, Shiflett MW, Jones MV, Ewell LA, Santhakumar V. Early deficits in dentate circuit and behavioral pattern separation after concussive brain injury. Exp Neurol. 2023 Dec;370:114578. doi: 10.1016/j.expneurol.2023.114578.
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Zanin JP, Pandya MA, Espinoza D, Friedman WJ, Shiflett MW. Excess cerebellar granule neurons induced by the absence of p75NTR during development elicit social behavior deficits in mice. Front Mol Neurosci. 2023 May 25;16:1147597. doi: 10.3389/fnmol.2023.1147597.
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Zanin, J., Verpeut, J., Li, Y., Shiflett, M.W., Wang, S.S., Santhakumar V., Friedman, W. The p75NTR influences cerebellar circuit development and adult behavior via regulation of cell cycle duration of granule cell progenitors Journal of Neuroscience (2019) 13;39(46):9119-9129 doi: 10.1523/JNEUROSCI.0990-19.